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Multiscale Modeling Of The Regulation OF Mitochondrial Function By Metabolites And Ultrastructure

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dc.contributor.advisor Jafri, M. Saleet Shukla, Sangeeta
dc.creator Shukla, Sangeeta 2016-04-19T19:28:47Z 2016-04-19T19:28:47Z 2015
dc.description.abstract Mitochondria are responsible for producing ATP, the energy currency in all living cells. To do this, the mitochondria have a complex micro-architecture upon which occur biomolecular processes that break down energy substrate to produce ATP. In heart which is constantly beating, mitochondrial energy metabolism is well regulated, allowing for increases during exercise. Energy metabolism is thought to be regulated both by changes in metabolite concentration as well as the micro-architecture of the cristae which are the folds in the mitochondrial inner membrane. The two questions addressed here are 1) how is calcium in the mitochondria regulated and what effect does this have on energy metabolism and 2) how does the cristae structure contribute to the regulation of energy metabolism. To this end, a multiscale computational modeling approach has been used to integrate experimental information across disparate scales and gain an understanding of the complex dynamics of this system.
dc.format.extent 148 pages
dc.language.iso en
dc.rights Copyright 2015 Sangeeta Shukla
dc.subject Bioinformatics en_US
dc.subject Systematic biology en_US
dc.subject Biophysics en_US
dc.subject Cellular Energy Metabolism en_US
dc.subject Mitochondrial ATP Production Efficiency en_US
dc.subject Mitochondrial Calcium Cycling en_US
dc.subject Mitochondrial Calcium Signaling en_US
dc.subject Mitochondrial Model en_US
dc.subject Mitochondrial Spatial Model en_US
dc.title Multiscale Modeling Of The Regulation OF Mitochondrial Function By Metabolites And Ultrastructure
dc.type Dissertation en Doctoral en Bioinformatics and Computational Biology en George Mason University en

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