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A Longitudinal Investigation into the Effect of Zn and Cu on Spatial Learning/Memory and Social Preference in a Mouse Model of LOAD

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dc.contributor.advisor Flinn, Jane M
dc.contributor.author Howell, Stefanie Nicole
dc.creator Howell, Stefanie Nicole
dc.date.accessioned 2017-01-29T01:13:07Z
dc.date.available 2017-01-29T01:13:07Z
dc.date.issued 2016
dc.identifier.uri http://hdl.handle.net/1920/10558
dc.description.abstract This study examined the effects of dietary copper (Cu) and zinc (Zn) on spatial learning/memory and social preference in a mouse model of late onset Alzheimer’s disease (AD). Previous research has indicated that excess dietary Zn may cause behavioral impairments through an induced Cu deficiency. Using a mildly Cu deficient hard diet, we initially tested this theory in an early onset model of AD, which suggested instead that 1.) the effects of Cu and Zn may differ in the brain regions controlling different behaviors, and that 2.) the effect of excess Zn may not be entirely due to an induced Cu deficiency.
dc.format.extent 63 pages
dc.language.iso en
dc.rights Copyright 2016 Stefanie Nicole Howell
dc.subject Neurosciences
dc.subject Psychology
dc.subject Alzheimer's disease
dc.subject Copper
dc.subject mouse model
dc.subject Zinc
dc.title A Longitudinal Investigation into the Effect of Zn and Cu on Spatial Learning/Memory and Social Preference in a Mouse Model of LOAD
dc.type Dissertation
thesis.degree.level Ph.D.
thesis.degree.discipline Psychology, Biopsychology Concentration
thesis.degree.grantor George Mason University


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