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Presence of Noncoding RNA and Exosomal Biogenesis in HIV Infection

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dc.contributor.advisor Kashanchi, Fatah Schwab, Angela
dc.creator Schwab, Angela 2016-07-22 2017-10-03T17:38:10Z 2017-10-03T17:38:10Z
dc.identifier doi:10.13021/G8NH46
dc.description.abstract HIV-1 infection can be treated with antiretroviral drugs, but an efficient system in quantifying latent HIV infection is necessary in a clinical setting. This study shows how nanoparticles can be used to capture exosomes that contain HIV-1 RNA transcripts in patient serum, CVL, and CSF. Multiple viral RNA transcripts of different lengths were found in exosomes from infected cells, including a novel transcript termed “TAR-gag”. Exosomes from HIV-infected cells cause recipient cells to become more susceptible to future infection. This study also shows how siRNA can be used to knock down key proteins involved in the formation of exosomes to decrease the amount of viral RNA transcripts released in these exosomes.
dc.language.iso en en_US
dc.subject HIV en_US
dc.subject exosome en_US
dc.subject siRNA en_US
dc.subject virus en_US
dc.subject nanoparticle en_US
dc.subject ESCRT en_US
dc.title Presence of Noncoding RNA and Exosomal Biogenesis in HIV Infection en_US
dc.type Thesis en_US Master of Science in Systems Biology en_US Master's en_US Systems Biology en_US George Mason University en_US

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