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Graph theoretic and motif analyses of the hippocampal neuron type potential connectome

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dc.contributor.author Ascoli, Giorgio A.
dc.contributor.author Rees, Christopher Loren
dc.contributor.author Wheeler, DW
dc.contributor.author Hamilton, DJ
dc.contributor.author White, CM
dc.contributor.author Komendantov, AO
dc.date.accessioned 2018-08-03T18:54:18Z
dc.date.available 2018-08-03T18:54:18Z
dc.date.issued 2016-11-07
dc.identifier.citation Rees, C. L., D. W. Wheeler, D. J. Hamilton, C. M. White, A. O. Komendantov, and G. A. Ascoli. “Graph Theoretic and Motif Analyses of the Hippocampal Neuron Type Potential Connectome.” ENeuro, November 7, 2016, ENEURO.0205-16.2016. https://doi.org/10.1523/ENEURO.0205-16.2016. en_US
dc.identifier.issn 2373-2822
dc.identifier.uri http://hdl.handle.net/1920/11073
dc.description.abstract We computed the potential connectivity map of all known neuron types in the rodent hippocampal formation by supplementing scantly available synaptic data with spatial distributions of axons and dendrites from the open-access knowledge base Hippocampome.org. The network that results from this endeavor, the broadest and most complete for a mammalian cortical region at the neuron-type level to date, contains more than 3,200 connections among 122 neuron types across six sub-regions. Analyses of these data employing graph theory metrics unveil the fundamental architectural principles of the hippocampal circuit. Globally, we identify a highly specialized topology minimizing communication cost; a modular structure underscoring the prominence of the tri-synaptic loop; a core set of neuron types serving as information processing hubs as well as a distinct group of particular anti-hub neurons; a nested, two-tier rich club managing much of the network traffic; and an innate resilience to random perturbations. At the local level, we uncover the basic building blocks, or connectivity patterns, that combine to produce complex global functionality, and we benchmark their utilization in the circuit relative to random networks. Taken together, these results provide a comprehensive connectivity profile of the hippocampus, yielding novel insights on its functional operations at the computationally crucial level of neuron types. en_US
dc.description.sponsorship NINDS R01NS39600 (NIH) NSF IIS-1302256 MURI N00014-10-1-0198 (ONR) CENTEC (AFOSR) en_US
dc.language.iso en_US en_US
dc.publisher eNeuro en_US
dc.rights Attribution 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by/3.0/us/ *
dc.subject Connectomics en_US
dc.subject Graph theory en_US
dc.subject Hippocampal neurons en_US
dc.subject Motifs en_US
dc.subject Neuroinformatics en_US
dc.subject Network en_US
dc.title Graph theoretic and motif analyses of the hippocampal neuron type potential connectome en_US
dc.type Article en_US
dc.identifier.doi 10.1523/ENEURO.0205-16.2016


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