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GENOMIC RESOURCES FOR CRYPTOSPORIDIUM SPECIES, HUMAN PATHOGENS OF PUBLIC HEALTH SIGNIFICANCE IN DEVELOPING COUNTRIES

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dc.contributor.advisor Silva, Joana CVaisman, Iosif
dc.contributor.author Ifeonu, Olukemi O
dc.creator Ifeonu, Olukemi O
dc.date.accessioned 2018-10-22T01:19:47Z
dc.date.available 2018-10-22T01:19:47Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/1920/11245
dc.description.abstract Cryptosporidium species are intracellular protozoan parasites, members of the phylum Apicomplexa that can infect the intestinal or gastric epithelial tissue of vertebrates, causing diarrhea. In immunocompromised individuals and young children, cryptosporidiosis can be life-threatening. Cryptosporidium was recently identified as a major cause of diarrhea-induced death of young children in developing countries. Despite the immense public health impact of Cryptosporidium infections in developing countries, no significant progress has been made towards developing a vaccine. Biological and technical challenges have impeded traditional vaccinology approaches to identify novel targets for the development of vaccines against this pathogen. The availability of genomic resources for multiple species in the genus has the potential to make a reverse vaccinology approach feasible. This dissertation describes the development and availability of new genomic tools and resources that should prove a valuable resource for the Cryptosporidium research community. This includes the annotated draft genome sequences of three species of Cryptosporidium, the Cryptosporidium hominis Gene Catalog, and the genome of a strain of anthroponotic Cryptosporidium parvum, and its analysis.
dc.format.extent 66 pages
dc.language.iso en
dc.rights Copyright 2017 Olukemi O Ifeonu
dc.subject Bioinformatics en_US
dc.subject Anthroponotic en_US
dc.subject Apicomplexan en_US
dc.subject Cryptosporidium en_US
dc.subject Gene catalog en_US
dc.subject Immunogen en_US
dc.subject Reverse vaccinolgy en_US
dc.title GENOMIC RESOURCES FOR CRYPTOSPORIDIUM SPECIES, HUMAN PATHOGENS OF PUBLIC HEALTH SIGNIFICANCE IN DEVELOPING COUNTRIES
dc.type Dissertation
thesis.degree.level Ph.D.
thesis.degree.discipline Bioinformatics and Computational Biology
thesis.degree.grantor George Mason University


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