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The Effects of Agaricus bisporus (White Button Mushrooms) on the Spatial Memory, Circadian Rhythms, and Daily Living Behavior in a Human Amyloid Precursor Protein (hAPP) Mouse Model

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dc.contributor.advisor Flinn, Jane
dc.contributor.author Dimopoulos, Thalia
dc.creator Dimopoulos, Thalia
dc.date 2019-12-05
dc.date.accessioned 2020-06-02T19:00:21Z
dc.date.available 2020-06-02T19:00:21Z
dc.identifier.uri http://hdl.handle.net/1920/11796
dc.description.abstract Alzheimer’s Disease (AD) affects 5.7 million Americans. White button mushrooms (WBMs) are considered an antioxidant due to their high source of selenium and have been shown to promote nerve growth factors (NGFs). Selenoproteins, particularly Selenoproteins M (SelM) and P (SelP), are an integral part of memory consolidation and preservation in mouse models. J20/hAPP transgenic mice and wildtype (C57BL/6J) mice were fed a 10% WBM feed three times per week to yield a 5% total diet of WBMs. Behavioral tests were conducted at 3.5 months and 8 months of age. During MWM, J20 mice on the WBM diet at 8 months of age were faster at reaching the platform compared to J20 mice on the control diet (p<0.014). In Western blots, J20 mice on the WBM diet had the greatest density of SelP compared to the other groups (p<0.015). en_US
dc.language.iso en en_US
dc.subject Alzheimer's disease en_US
dc.subject mushrooms en_US
dc.subject spatial memory en_US
dc.subject selenoproteins en_US
dc.title The Effects of Agaricus bisporus (White Button Mushrooms) on the Spatial Memory, Circadian Rhythms, and Daily Living Behavior in a Human Amyloid Precursor Protein (hAPP) Mouse Model en_US
dc.type Thesis en_US
thesis.degree.name Master of Arts in Psychology en_US
thesis.degree.level Master's en_US
thesis.degree.discipline Psychology en_US
thesis.degree.grantor George Mason University en_US


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