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The Effects of Adolescent Nicotine Exposure on Dendritic Morphology in the Bed Nucleus of the Stria Terminalis

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dc.contributor.advisor Smith, Robert F.
dc.contributor.author Brown, Kelsey
dc.creator Brown, Kelsey
dc.date 2012-07-19
dc.date.accessioned 2012-10-08T14:20:17Z
dc.date.available NO_RESTRICTION en_US
dc.date.available 2012-10-08T14:20:17Z
dc.date.issued 2012-10-08
dc.identifier.uri http://hdl.handle.net/1920/7964
dc.description.abstract Nicotine has been shown to increase the risk of anxiety related disorders in adulthood (Slawecki, Gilder, Roth, & Ehlers, 2003). Early nicotine exposure may negatively affect the development of the adolescent brain(Morissette, Tull, Gulliver, Kamholz, & Zimering, 2007). The bed nucleus of the stria terminalis has been shown to have major projections to the PVNmp that regulates the brain and body’s reaction to stress as well as influences activity of the HPA axis. This study investigated morphological changes of dendrites on neurons located in the bed nucleus of the stria terminalis following adolescent nicotine exposure. Male Sprague-Dawley rats were administered nicotine (0.5mg/kg/day) 3 days a week for 2 consecutive weeks, starting at postnatal day P (32). 17 days following the end of dosing, at postnatal day P (60), brains were processed for Golgi-Cox staining and neurons were digitally reconstructed for branch order and Sholl(Sholl, 1953) analysis. Nicotine pretreatment produced an increase in the number of bifurcations and total length of dendrites. Nicotine pretreatment also increased the average length of dendrites, suggesting that growth of existing branches is occurring as well as formation of new branches. Sholl analysis also revealed an increase in the number of intersections with concentric spheres, increased amount of dendritic material within concentric spheres, and an increase of dendritic branching within concentric spheres occurring between 20-300μm from the soma in dendrites. en_US
dc.language.iso en en_US
dc.subject bed nucleus of the stria terminalis en_US
dc.subject adolescent en_US
dc.subject nicotine en_US
dc.subject anxiety en_US
dc.subject addiction en_US
dc.subject rats en_US
dc.title The Effects of Adolescent Nicotine Exposure on Dendritic Morphology in the Bed Nucleus of the Stria Terminalis en_US
dc.type Thesis en
thesis.degree.name Master of Arts in Psychology en_US
thesis.degree.level Master's en
thesis.degree.discipline Psychology en
thesis.degree.grantor George Mason University en


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