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MIAMI: A Graphical Interface Web-Tool for Integrated miRNA-mRNA Interaction Analyses in Drosophila melanogaster

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dc.contributor.advisor Willett, James D.
dc.contributor.author Patel, Jaimin
dc.creator Patel, Jaimin
dc.date 2012-11-26
dc.date.accessioned 2013-02-18T20:12:47Z
dc.date.available NO_RESTRICTION en_US
dc.date.available 2013-02-18T20:12:47Z
dc.date.issued 2013-02-18
dc.identifier.uri https://hdl.handle.net/1920/8026
dc.description.abstract This thesis describes the design and implementation of a web-based tool – MIAMI (miRNA and mRNA integrated analysis) – that enables integrative analysis of target predictions, miRNA and gene expression data. MIAMI is divided into two parts: the query section and the analysis section. The query section allows the user to retrieve and browse updated miRNA-mRNA pairs predicted using a number of different computational algorithms such as PITA, miRanda and Target Scan as well as Boolean combinations of these algorithms. The analysis section comprises a multi-step procedure for (i) performing various statistical analyses of mRNA and miRNA expression data; (ii) visualization of networks of the highest confidence miRNA and mRNA interactions and; (iii) retrieval of gene, miRNA and disease-specific information available in several public databases via scientific literature text-mining.
dc.language.iso en en_US
dc.subject miRNA-mRNA en_US
dc.subject Drosophilia melanogaster en_US
dc.subject Graphical Interface Web Tool en_US
dc.subject MIAMI en_US
dc.subject target prediction algorithms en_US
dc.subject Network Visualization en_US
dc.title MIAMI: A Graphical Interface Web-Tool for Integrated miRNA-mRNA Interaction Analyses in Drosophila melanogaster en_US
dc.type Thesis en
thesis.degree.name Master of Science in Bioinformatics and Computational Biology en_US
thesis.degree.level Master's en
thesis.degree.discipline Bioinformatics and Computational Biology en
thesis.degree.grantor George Mason University en


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