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A Role of Visceral Adipose and Gastric Tissue in Inflammatory Conditions Associated With Metabolic Syndrome

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dc.contributor.advisor Baranova, Ancha Mehta, Rohini
dc.creator Mehta, Rohini 2013-05 2013-08-15T16:42:12Z 2014-07-15T21:36:46Z 2013-08-15
dc.description.abstract Obesity has reached epidemic proportions globally. Obesity is accompanied by co-morbidities affecting multiple peripheral tissues. Obesity associated non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the US. The molecular mechanisms underlying the development and the progression of NAFLD, however, remain poorly understood. Stomach is an important endocrine organ that produces a number of bioactive peptides with important roles in the metabolism of energy. Stomach is located in the vicinity of the liver, but so far it has been largely neglected as an organ with potentially important role in obesity and associated NAFLD. This study provides the evidence for the contribution of the stomach-specific expression changes in a number of molecules previously implicated in inflammation and energy homeostasis to the pathogenesis of obesity-associated NAFLD. White adipose tissue (WAT) represents the majority of adipose tissue in humans, is the main fat storage organ. In contrast, brown adipose tissue (BAT) has a unique ability to spend energy through producing heat in mitochondrial "uncoupling". The facultative nature of BAT activity and its distribution within WAT depots complicate the detection of BAT in adult humans. In this study, the expression of genes involved in transcriptional regulation of brown adipocyte-specific UCP1 gene and BAT differentiation was assessed as quantitative indicator of BAT activity in adipose of adult humans.
dc.language.iso en_US en_US
dc.rights Copyright 2013 Rohini Mehta en_US
dc.subject Stomach en_US
dc.subject Visceral en_US
dc.subject Brown Adipose Tissue en_US
dc.subject Gastric en_US
dc.subject Gene Expression en_US
dc.subject Obesity en_US
dc.title A Role of Visceral Adipose and Gastric Tissue in Inflammatory Conditions Associated With Metabolic Syndrome en_US
dc.type Dissertation en
dc.description.note This work is embargoed by the author and will not be available until June 2014. en_US PhD in Biosciences en_US Doctoral en Biosciences en George Mason University en

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