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Bioaerosol Dispersal Models and the In Silico Design of a Synthetic Strain of Bacillus subtilis with Stringent Growth Regulation

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dc.contributor.advisor Popov, Serguei
dc.contributor.author Riojas, Marco A. en_US
dc.creator Riojas, Marco A. en_US
dc.date.accessioned 2015-02-12T02:57:00Z
dc.date.available 2015-02-12T02:57:00Z
dc.date.issued 2014 en_US
dc.identifier.uri http://hdl.handle.net/1920/9156
dc.description.abstract A critical component of biodefense research is the modeling and simulation of the spread of Bacillus anthracis spores. Of the three primary approaches used to study the dispersal of such bioaerosols - mathematical modeling, physical simulation, and biological simulation - the direct dispersal of biological simulants offers the most accurate results. However, the dispersal of viable simulants risks colonization of undesired environments, such as immunocompromised persons within exposed populations. During its Cold War biological weapons research program, the US government dispersed biologically viable simulants, exposing human subjects (often unbeknownst to them) to these ostensibly safe but potentially pathogenic organisms. An analysis of these open-air tests illustrates three improvements to ensure that future biodefense research is conducted ethically: reduced pathogenicity of the biological simulant, obtaining informed consent (either standard or de facto) from potentially exposed populations, and ensuring that the unique concerns regarding military bioethics are addressed for any military service members who may be exposed. en_US
dc.format.extent 405 pages en_US
dc.language.iso en en_US
dc.rights Copyright 2014 Marco A. Riojas en_US
dc.subject Political Science en_US
dc.subject Molecular biology en_US
dc.subject Public policy en_US
dc.subject Bacillus anthracis en_US
dc.subject Bacillus subtilis en_US
dc.subject bioaerosol dispersal en_US
dc.subject bioethics en_US
dc.subject simulant systems en_US
dc.subject synthetic biology en_US
dc.title Bioaerosol Dispersal Models and the In Silico Design of a Synthetic Strain of Bacillus subtilis with Stringent Growth Regulation en_US
dc.type Dissertation en
thesis.degree.level Doctoral en
thesis.degree.discipline Biodefense en
thesis.degree.grantor George Mason University en


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