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Protein Phosphatase 1 Alpha Modulates L Polymerase Phosphorylation and Regulates Rift Valley Fever Virus Replication

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dc.contributor.advisor Kehn-Hall, Kylene
dc.contributor.author Baer, Alan
dc.creator Baer, Alan
dc.date 2015-08
dc.date.accessioned 2015-09-18T15:32:01Z
dc.date.issued 2015-09-18
dc.identifier.uri http://hdl.handle.net/1920/9891
dc.description This work was embargoed by the author and will not be publicly available until August 2020. en_US
dc.description.abstract Members of the Bunyaviridae family are amongst the most widespread viruses in the world. Rift Valley fever virus (RVFV), family Bunyaviridae, is a mosquito-borne phlebovirus capable of causing cyclic Rift Valley fever epidemics devastating both livestock and human populations throughout sub-Saharan Africa. Despite being recognized as an emerging threat, relatively little is known about the virulence mechanisms of RVFV, or the host factors involved in viral pathogenesis. Currently there are no FDA licensed vaccines or therapeutics to treat RVF. The Ser/Thr cellular kinase Protein Phosphatase 1 (PP1) is an attractive target for viral manipulation as it is involved in numerous host signaling events. en_US
dc.language.iso en_US en_US
dc.rights Copyright 2015 Alan Baer en_US
dc.subject Biology en_US
dc.title Protein Phosphatase 1 Alpha Modulates L Polymerase Phosphorylation and Regulates Rift Valley Fever Virus Replication en_US
dc.type Dissertation en
thesis.degree.name PhD in Biosciences en_US
thesis.degree.level Doctoral en
thesis.degree.discipline Systems Biology en
thesis.degree.grantor George Mason University en
dc.description.embargo 2020-08-15


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