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Time-Dependent Increase in Network Response to Stimulation

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dc.contributor.author Hamilton, Franz
dc.contributor.author Graham, Robert
dc.contributor.author Luu, Lydia
dc.contributor.author Peixoto, Nathalia
dc.date.accessioned 2015-11-18T15:44:46Z
dc.date.available 2015-11-18T15:44:46Z
dc.date.issued 2015-11-06
dc.identifier.citation Hamilton F, Graham R, Luu L, Peixoto N (2015) Time-Dependent Increase in Network Response to Stimulation. PLoS ONE 10(11): e0142399. en_US
dc.identifier.uri https://hdl.handle.net/1920/10023
dc.description.abstract In vitro neuronal cultures have become a popular method with which to probe network-level neuronal dynamics and phenomena in controlled laboratory settings. One of the key dynamics of interest in these in vitro studies has been the extent to which cultured networks display properties indicative of learning. Here we demonstrate the effects of a high frequency electrical stimulation signal in training cultured networks of cortical neurons. Networks receiving this training signal displayed a time-dependent increase in the response to a low frequency probing stimulation, particularly in the time window of 20–50 ms after stimulation. This increase was found to be statistically significant as compared to control networks that did not receive training. The timing of this increase suggests potentiation of synaptic mechanisms. To further investigate this possibility, we leveraged the powerful Cox statistical connectivity method as previously investigated by our group. This method was used to identify and track changes in network connectivity strength.
dc.description.sponsorship This work was funded by National Science Foundation grant CMMI-1300007 (NP received the funding). Publication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.rights Attribution 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by/3.0/us/ *
dc.subject In vitro neuronal cultures en_US
dc.subject neuronal dynamics en_US
dc.subject electrical stimulation en_US
dc.subject neural networks en_US
dc.subject electrode recording en_US
dc.title Time-Dependent Increase in Network Response to Stimulation en_US
dc.type Article en_US
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0142399


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