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Distinct and synergistic feedforward inhibition of pyramidal cells by basket and bistratified interneurons

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dc.contributor.author Ferrante, Michele
dc.contributor.author Ascoli, Giorgio A.
dc.date.accessioned 2016-07-27T17:27:21Z
dc.date.available 2016-07-27T17:27:21Z
dc.date.issued 2015-11-05
dc.identifier.citation Ferrante M and Ascoli GA (2015) Distinct and synergistic feedforward inhibition of pyramidal cells by basket and bistratified interneurons. Front. Cell. Neurosci. 9:439. doi: 10.3389/fncel.2015.00439 en_US
dc.identifier.uri https://hdl.handle.net/1920/10309
dc.description.abstract Feedforward inhibition (FFI) enables pyramidal cells in area CA1 of the hippocampus (CA1PCs) to remain easily excitable while faithfully representing a broad range of excitatory inputs without quickly saturating. Despite the cortical ubiquity of FFI, its specific function is not completely understood. FFI in CA1PCs is mediated by two physiologically and morphologically distinct GABAergic interneurons: fast-spiking, perisomatic-targeting basket cells and regular-spiking, dendritic-targeting bistratified cells. These two FFI pathways might create layer-specific computational sub-domains within the same CA1PC, but teasing apart their specific contributions remains experimentally challenging. We implemented a biophysically realistic model of CA1PCs using 40 digitally reconstructed morphologies and constraining synaptic numbers, locations, amplitude, and kinetics with available experimental data. First, we validated the model by reproducing the known combined basket and bistratified FFI of CA1PCs at the population level. We then analyzed how the two interneuron types independently affected the CA1PC spike probability and timing as a function of inhibitory strength. Separate FFI by basket and bistratified respectively modulated CA1PC threshold and gain. Concomitant FFI by both interneuron types synergistically extended the dynamic range of CA1PCs by buffering their spiking response to excitatory stimulation. These results suggest testable hypotheses on the precise effects of GABAergic diversity on cortical computation.
dc.description.sponsorship This work was supported in part by National Institutes of Health grant R01 NS39600, Office of Naval Research grant MURI N00014-10-1-0198, and National Science Foundation grant RI IIS-1302256 to GAA. Publication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund. en_US
dc.language.iso en_US en_US
dc.publisher Frontiers en_US
dc.subject feedforward inhibiton en_US
dc.subject bistratified en_US
dc.subject basket en_US
dc.subject interneurons en_US
dc.subject CA1 pyramidal cells en_US
dc.subject neuronal connectivity en_US
dc.subject hippocampus en_US
dc.subject input-output transformation en_US
dc.title Distinct and synergistic feedforward inhibition of pyramidal cells by basket and bistratified interneurons en_US
dc.type Article en_US
dc.identifier.doi http://dx.doi.org/10.3389/fncel.2015.00439


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