Abstract:
New approaches and therapies to deliver current drugs are always being sought to
improve upon conventional techniques. The method of producing drug nanoaerosol
particles based on the Electrospray Neutralization technique is proposed as a new
approach in the treatment of lung diseases by delivering drugs deep into lung tissue,
increasing their bioavailability as a result of bypassing first-pass metabolism in the liver,
and reducing the toxicity and effective dose over oral administration. The goal of this
work is to test the applicability of the Electrospray Neutralization technique to generate
nanoaerosols from different drug substances and to evaluate how solubility, ionic state,
and other physical and chemical properties of drugs affect nanoaerosol generation. Size
and mass spectra of generated nanoaerosol particles were taken for fourteen drugs and
potential inhaled doses were estimated for humans and mice. It was found that the
generator produced nanoaerosol particles with an average geometric size of 30-40 nm for
most drugs electrosprayed from 0.1 % solutions in water. Multiple Path Particle Dosimetry (MPPD) modeling of the total and regional lung deposition predict that
humans will get doses of approximately 1 μg/kg/hour and mice will receive
approximately 30 μg/kg/hour.
