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Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation

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dc.contributor.author Owen, Jeremy A.
dc.contributor.author Barreto, Ernest
dc.contributor.author Cressman, John R.
dc.date.accessioned 2015-10-29T15:58:12Z
dc.date.available 2015-10-29T15:58:12Z
dc.date.issued 2013-09-16
dc.identifier.citation Owen JA, Barreto E, Cressman JR (2013) Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation. PLoS ONE 8(9): e73820. doi:10.1371/journal.pone.0073820 en_US
dc.identifier.uri http://hdl.handle.net/1920/9996
dc.description.abstract We investigate the effects of adding periodic stimulation to a generic, conductance-based neuron model that includes ion concentration dynamics of sodium and potassium. Under conditions of high extracellular potassium, the model exhibits repeating, spontaneous, seizure-like bursting events associated with slow modulation of the ion concentrations local to the neuron. We show that for a range of parameter values, depolarizing and hyperpolarizing periodic stimulation pulses (including frequencies lower than 4 Hz) can stop the spontaneous bursting by interacting with the ion concentration dynamics. Stimulation can also control the magnitude of evoked responses to modeled physiological inputs. We develop an understanding of the nonlinear dynamics of this system by a timescale separation procedure that identifies effective nullclines in the ion concentration parameter space. Our results suggest that the manipulation of ion concentration dynamics via external or endogenous stimulation may play an important role in neuronal excitability, seizure dynamics, and control. en_US
dc.description.sponsorship Publication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund, JRC Start up funds, and EB NIH CRCNS R01-MH079502 (National Institutes of Health Collaborative Research in Computational Neuroscience. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.rights Attribution 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by/3.0/us/ *
dc.subject neurons en_US
dc.subject action potentials en_US
dc.subject epilepsy en_US
dc.subject tetanus en_US
dc.subject membrane potential en_US
dc.subject electrical stimulation en_US
dc.subject potassium en_US
dc.subject intracellular membranes en_US
dc.title Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation en_US
dc.type Article en_US
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0073820


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