ASAIO GOLD
The 25 Landmark ‘Milestone’ Papers
Published by ASAIO
1955-2003
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Your Commentary --- Milestone Papers to Add
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Artificial
Cells
1.
Chang TM: Semi-permeable aqueous micro capsules
(artificial cells) with emphasis on experience in extracorporeal systems.
TASAIO 12:13-19, 1966.
Commentary: Dr. Thomas
Ming Swi Chang is the originator of "artificial
cells". In this paper he discusses studies on the use of an extracorporeal
shunt containing microcapsules with the enzyme urease
to breakdown urea to form ammonia for the application in the treatment of renal
failure. He also discusses approaches for microencapsulation
of detoxifying agents as resins and charcoals to improve biocompatibility in
blood contacting applications and for microcapsules containing red cell hemolysates such as artificial red cells. This paper builds
on his pioneering work from just years earlier.
Dr. Chang built his career and laboratory focused on
the area of microencapsulation and "cells"
for medical applications such as related to the artificial kidney, artificial
liver, detoxification, enzyme therapy, etc. since his Ph.D. work on "Semipermeable Aqueous Microcapsules". In addition to
this focus he is also recognized for his work in the artificial blood field on
hemoglobin type products. -- Paul S. Malchesky, D.Eng.
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