Not so cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction

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dc.contributor.authorKabbani, Nadine
dc.date.accessioned2015-10-29T16:00:09Z
dc.date.available2015-10-29T16:00:09Z
dc.date.issued2013-07-23
dc.description.abstractNicotine cigarette smoke is a large public health burden worldwide, contributing to various types of disease. Anti-tobacco media campaigns and control programs have significantly reduced smoking in the United States, yet trends for menthol cigarette smoking have not been as promising. Menthol cigarette smoking is particularly prevalent among young adults and African Americans, with implications for long-term impacts on health care. Continuing high rates of menthol cigarette addiction call into question the role of menthol in nicotine addiction. To date, a biological basis for the high rate of addiction and relapse among menthol cigarette smokers has not been defined. Studies have demonstrated a role for menthol in the metabolism of nicotine in the body. More recent findings now reveal an interaction between menthol and the nicotinic acetylcholine (nACh) receptor in cells. This receptor is central to the actions of nicotine in the brain, and plays an important role in nicotine addiction. The newly discovered effect of menthol on nACh receptors may begin to explain the unique addictive properties of menthol cigarettes.
dc.description.sponsorshipThis work is supported by a VYTP Grant Award on Research on the Causes and Prevention of Youth Tobacco to Nadine Kabbani. Publication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund.
dc.identifier.citationKabbani N (2013) Not so cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction. Front. Pharmacol. 4:95. doi: 10.3389/fphar.2013.00095
dc.identifier.doihttp://dx.doi.org/10.3389/fphar.2013.00095
dc.identifier.urihttps://hdl.handle.net/1920/9997
dc.language.isoen_US
dc.publisherFrontiers
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subjectMenthol
dc.subjectAddiction research
dc.subjectAfrican Americans
dc.subjectNicotinic receptors
dc.subjectTobacco
dc.titleNot so cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction
dc.typeArticle

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