An Investigation into the Role of Dietary Copper and Zinc on Copper/Zinc Cellular Bioavailability, Inflammation, and Species Typical Behaviors in a Late Onset Mouse Model of Alzheimer’s Disease

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dc.contributor.advisorFlinn, Jane M
dc.contributor.authorBoggs, Katelyn Nicole
dc.creatorBoggs, Katelyn Nicole
dc.date.accessioned2018-10-21T19:17:21Z
dc.date.available2018-10-21T19:17:21Z
dc.date.issued2017
dc.description.abstractResearch in the field of Alzheimer’s disease (AD) often focuses on the early onset form (EOAD); however, the majority of AD cases are late onset (LOAD). The reason for this is the genetic nature of EOAD, and thus relative ease of developing animal models for EOAD through genetic manipulation. The present study was an attempt to model LOAD in mice by crossing the J20 mouse, which overexpresses human mutated amyloid precursor protein (hAPP), with the ApoE4 mouse, which expresses the E4 allele of the apolipoprotein, resulting in J20/E4 offspring. The E4 allele is the only known genetic risk factor for the development of LOAD.
dc.format.extent79 pages
dc.identifier.urihttps://hdl.handle.net/1920/11153
dc.language.isoen
dc.rightsCopyright 2017 Katelyn Nicole Boggs
dc.subjectNeurosciences
dc.subjectAlzheimer's disease
dc.subjectApoE4
dc.subjectAPP
dc.subjectBurrowing
dc.subjectNesting
dc.titleAn Investigation into the Role of Dietary Copper and Zinc on Copper/Zinc Cellular Bioavailability, Inflammation, and Species Typical Behaviors in a Late Onset Mouse Model of Alzheimer’s Disease
dc.typeDissertation
thesis.degree.disciplinePsychology
thesis.degree.grantorGeorge Mason University
thesis.degree.levelPh.D.

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