Protein Phosphatase 1 Alpha Modulates L Polymerase Phosphorylation and Regulates Rift Valley Fever Virus Replication

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dc.contributor.advisorKehn-Hall, Kylene
dc.contributor.authorBaer, Alan
dc.creatorBaer, Alan
dc.date2015-08
dc.date.accessioned2015-09-18T15:32:01Z
dc.date.available2020-08-15T06:47:15Z
dc.date.issued2015-09-18
dc.descriptionThis work was embargoed by the author and will not be publicly available until August 2020.
dc.description.abstractMembers of the Bunyaviridae family are amongst the most widespread viruses in the world. Rift Valley fever virus (RVFV), family Bunyaviridae, is a mosquito-borne phlebovirus capable of causing cyclic Rift Valley fever epidemics devastating both livestock and human populations throughout sub-Saharan Africa. Despite being recognized as an emerging threat, relatively little is known about the virulence mechanisms of RVFV, or the host factors involved in viral pathogenesis. Currently there are no FDA licensed vaccines or therapeutics to treat RVF. The Ser/Thr cellular kinase Protein Phosphatase 1 (PP1) is an attractive target for viral manipulation as it is involved in numerous host signaling events.
dc.identifier.urihttps://hdl.handle.net/1920/9891
dc.language.isoen_US
dc.rightsCopyright 2015 Alan Baer
dc.subjectBiology
dc.titleProtein Phosphatase 1 Alpha Modulates L Polymerase Phosphorylation and Regulates Rift Valley Fever Virus Replication
dc.typeDissertation
thesis.degree.disciplineSystems Biology
thesis.degree.grantorGeorge Mason University
thesis.degree.levelDoctoral
thesis.degree.namePhD in Biosciences

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