Statistical Analysis of mRNA-miRNA Interaction
Date
2013-12-03
Authors
Bhattacharya, Surajit
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Abstract
The basic concept of our web tool is to develop an integrative analysis of target prediction together with miRNA and gene expression data obtained from microarray data of Drosophila. The web tool can be broadly classified into two parts: Query Section and Analysis Section. The Query Section allows users to retrieve and browse different target prediction databases including PITA, Miranda and TargetScan. The Analysis Section depends upon the statistical approach to predicting the miRNA-mRNA targets. The statistical part can be broadly classified into three components: A) The parametric (Pearson) correlation), B) Distance Correlation and C) Brownian Covariance. Statistical calculation was done in R. The graphical representation of the interaction would be obtained by ggplot, an R package.
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Keywords
MiRNA-mRNA target prediction, Brownian covariance, Pearson correlation, Distance correlation