The effect of a specific Heat Shock Protein 90 inhibitor on HIV-1 infection

dc.creator	Sarah Pierson
dc.date.accessioned	2022-01-25T19:24:02Z
dc.date.available	2022-01-25T19:24:02Z
dc.date.issued	2020
dc.description.abstract	This thesis describes the effort to characterize several intracellular signaling and transport molecules during HIV-1 infection via chemical inhibition. Many pharmaceutical molecules developed for one purpose find a second or third life in the treatment of another medical condition. The cellular changes resulting from cancer in some cases resemble changes in signaling which occurs during HIV-1 infection. During the course of this research, several pathways of signaling were variously knocked down, or otherwise inhibited using multiple methods to determine if one or more already-developed chemical compounds could be useful in the treatment or study of HIV-1 disease. During the course of this research and writing, the author conducted numerous literature searches and laboratory investigations to develop the evidence necessary to demonstrate one cell-signaling pathway that is vital to viral infection. The inhibition of the heat shock protein 90 protein leads to the conclusion that tanespimycin impacts viral infection in the described models.
dc.identifier.uri	https://hdl.handle.net/1920/12571
dc.title	The effect of a specific Heat Shock Protein 90 inhibitor on HIV-1 infection
thesis.degree.discipline	Biosciences
thesis.degree.grantor	George Mason University
thesis.degree.level	Ph.D.

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