Role of KCNRG in B-CELL Chronic Lymphocytic Leukemia

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dc.contributor.authorBirerdinc, Aybike
dc.creatorBirerdinc, Aybike
dc.date2008-12-02
dc.date.accessioned2008-12-22T21:05:08Z
dc.date.availableNO_RESTRICTION
dc.date.available2008-12-22T21:05:08Z
dc.date.issued2008-12-22T21:05:08Z
dc.description.abstractB-cell chronic lymphocyte leukemia (B-CLL) accounts for approximately 30% of all leukemias in the Western world and has so far been treated with variable success. The newly characterized KCNRG gene has been mapped to chromosome 13q14.3. KCNRG is thought to be a tumor suppressor gene involved in the development of B-cell chronic lymphocytic leukemia due to its significant homology to the tetramerization (T1) domain of the voltage-gated potassium channels (Kv channels) and an ability to suppress growth-stimulating Kv currents. Since point mutations of KCNRG have not been found in B-CLL samples, a novel approach for its study based on a haploinsufficiency model was suggested. The aim of this study is to determine whether the KCNRG gene functions as growth suppressor in tumor cell lines and to elucidate a putative role for the loss of this gene in the development and the progression of B-CLL. Overexpression studies of KCNRG were performed in an attempted to determine the involvement of KCNRG in apoptosis, differentiation, and invasion of cultured human tumor cells, and the effects of overexpression of KCNRG on gene expression and proteomics profiles were quantified.
dc.identifier.urihttps://hdl.handle.net/1920/3365
dc.language.isoen_US
dc.subjectKCNRG
dc.subjectB-CLL
dc.subjectHaploinsufficiency
dc.subjectTumor Suppressor Gene (TSG)
dc.subject13q14
dc.subjectPotassium Channels
dc.titleRole of KCNRG in B-CELL Chronic Lymphocytic Leukemia
dc.typeDissertation
thesis.degree.disciplineBiosciences
thesis.degree.grantorGeorge Mason University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy in Biosciences

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