Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation

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dc.contributor.authorOwen, Jeremy A.
dc.contributor.authorBarreto, Ernest
dc.contributor.authorCressman, John R.
dc.date.accessioned2015-10-29T15:58:12Z
dc.date.available2015-10-29T15:58:12Z
dc.date.issued2013-09-16
dc.description.abstractWe investigate the effects of adding periodic stimulation to a generic, conductance-based neuron model that includes ion concentration dynamics of sodium and potassium. Under conditions of high extracellular potassium, the model exhibits repeating, spontaneous, seizure-like bursting events associated with slow modulation of the ion concentrations local to the neuron. We show that for a range of parameter values, depolarizing and hyperpolarizing periodic stimulation pulses (including frequencies lower than 4 Hz) can stop the spontaneous bursting by interacting with the ion concentration dynamics. Stimulation can also control the magnitude of evoked responses to modeled physiological inputs. We develop an understanding of the nonlinear dynamics of this system by a timescale separation procedure that identifies effective nullclines in the ion concentration parameter space. Our results suggest that the manipulation of ion concentration dynamics via external or endogenous stimulation may play an important role in neuronal excitability, seizure dynamics, and control.
dc.description.sponsorshipPublication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund, JRC Start up funds, and EB NIH CRCNS R01-MH079502 (National Institutes of Health Collaborative Research in Computational Neuroscience.
dc.identifier.citationOwen JA, Barreto E, Cressman JR (2013) Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation. PLoS ONE 8(9): e73820. doi:10.1371/journal.pone.0073820
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0073820
dc.identifier.urihttps://hdl.handle.net/1920/9996
dc.language.isoen_US
dc.publisherPublic Library of Science
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subjectNeurons
dc.subjectAction potential
dc.subjectEpilepsy
dc.subjectTetanus
dc.subjectMembrane potential
dc.subjectElectrical stimulation
dc.subjectPotassium
dc.subjectIntracellular membranes
dc.titleControlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation
dc.typeArticle

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