Age-Independent Rise of Inflammatory Scores May Contribute to Accelerated Aging in Multi-Morbidity

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dc.contributor.authorStepanova, Maria
dc.contributor.authorRodriguez, Edgar
dc.contributor.authorBirerdinc, Aybike
dc.contributor.authorBaranova, Ancha
dc.date.accessioned2015-09-16T15:53:32Z
dc.date.available2015-09-16T15:53:32Z
dc.date.issued2015-02-10
dc.description.abstractAging is associated with an increase in a chronic, low-grade inflammation. This phenomenon, termed “inflammaging” is also a risk factor for both morbidity and mortality in the elderly. Frequent co-occurrence of chronic diseases, known as multi-morbidity, may be explained by interconnected pathophysiology of these conditions, most of which depend on its inflammatory component. Here we present an analysis of the U.S. National Health and Nutrition Examination Survey data collected between 1999 and 2008, for the presence, and the number, of chronic diseases along with HDL-cholesterol, C-reactive protein, white blood cell count, lymphocyte percent, monocyte percent, segmented neutrophils percent, eosinophils percent, basophils percent, and glycohemoglobin levels. Importantly, even after adjustment for age and BMI, many inflammatory markers continued to be associated to multi-morbidity. C-reactive protein (CRP) levels and Glasgow Prognostic Score (GPS) were most dramatically increased in parallel with an accumulation of chronic diseases, and may be utilized as multi-morbidity predictors. These observations point at background inflammation as direct, age-independent contributor to an accumulation of the disease burden. Our findings also suggest a possibility that systemic inflammation associated with chronic diseases may explain accelerated aging phenomenon previously observed among the patients with heavy disease burden.
dc.description.sponsorshipPublication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund
dc.identifier.citationStepanova, M., Rodriguez, E., Birerdinc, A., & Baranova, A. (2015). Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity. Oncotarget, 6(3), 1414-1421.
dc.identifier.doihttp://dx.doi.org/10.18632/oncotarget.2725
dc.identifier.doihttp://dx.doi.org/10.18632/oncotarget.2725
dc.identifier.urihttps://hdl.handle.net/1920/9887
dc.language.isoen_US
dc.publisherImpact Journals, LLC
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subjectMulti-morbidit
dc.subjectC-reactive protein
dc.subjectSystemic inflammation
dc.subjectGlasgow Prognostic Score
dc.subjectAging
dc.titleAge-Independent Rise of Inflammatory Scores May Contribute to Accelerated Aging in Multi-Morbidity
dc.typeArticle

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