VOC Metabolomics: Medicinal Applications and Methodological Improvements

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dc.contributor.advisorCouch, Robin D.
dc.contributor.authorNavarro, Karl Anthony
dc.creatorNavarro, Karl Anthony
dc.date2014-04-25
dc.date.accessioned2014-10-07T14:44:17Z
dc.date.available2015-04-29T20:13:43Z
dc.date.issued2014-10-07
dc.description.abstractMetabolomics, the science of extracting and analyzing small molecule metabolites from a given sample matrix, has become the method of choice for investigations ranging from environmental to human-health related issues. Solid-phase microextraction (SPME) fibers can be used to extract metabolites as volatile organic compounds (VOCs) from the sample headspace. VOCs were analyzed via gas chromatography-mass spectrometry (GC-MS) and were identified using Automated Mass Spectral Deconvolution Identification System (AMDIS) software and the National Institutes of Standards and Technology (NIST) database. This methodology was applied to differentiate alcoholic patients from healthy controls in an attempt to develop a non-invasive indication of alcoholism. Fecal samples were collected from patients after home passage (defecation into a specimen bag) and via endoscopy. These samples were used to justify endoscopy collected fecal samples, establish the extraction duration (18 hours or 20 minutes) better
dc.description.noteThis thesis has been embargoed for 1 year and will not be available until April 25, 2015.
dc.identifier.urihttps://hdl.handle.net/1920/9000
dc.language.isoen
dc.subjectVOC Metabolomics
dc.subjectH-SPME
dc.subjectWhipworm treatment
dc.subjectMultiple extraction device
dc.subjectAlcohol liver disease
dc.titleVOC Metabolomics: Medicinal Applications and Methodological Improvements
dc.typeThesis
thesis.degree.disciplineChemistry
thesis.degree.grantorGeorge Mason University
thesis.degree.levelMaster's
thesis.degree.nameMaster of Science in Chemistry

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