Time-Dependent Increase in Network Response to Stimulation

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dc.contributor.authorHamilton, Franz
dc.contributor.authorGraham, Robert
dc.contributor.authorLuu, Lydia
dc.contributor.authorPeixoto, Nathalia
dc.date.accessioned2015-11-18T15:44:46Z
dc.date.available2015-11-18T15:44:46Z
dc.date.issued2015-11-06
dc.description.abstractIn vitro neuronal cultures have become a popular method with which to probe network-level neuronal dynamics and phenomena in controlled laboratory settings. One of the key dynamics of interest in these in vitro studies has been the extent to which cultured networks display properties indicative of learning. Here we demonstrate the effects of a high frequency electrical stimulation signal in training cultured networks of cortical neurons. Networks receiving this training signal displayed a time-dependent increase in the response to a low frequency probing stimulation, particularly in the time window of 20–50 ms after stimulation. This increase was found to be statistically significant as compared to control networks that did not receive training. The timing of this increase suggests potentiation of synaptic mechanisms. To further investigate this possibility, we leveraged the powerful Cox statistical connectivity method as previously investigated by our group. This method was used to identify and track changes in network connectivity strength.
dc.description.sponsorshipThis work was funded by National Science Foundation grant CMMI-1300007 (NP received the funding). Publication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund.
dc.identifier.citationHamilton F, Graham R, Luu L, Peixoto N (2015) Time-Dependent Increase in Network Response to Stimulation. PLoS ONE 10(11): e0142399.
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0142399
dc.identifier.urihttps://hdl.handle.net/1920/10023
dc.language.isoen_US
dc.publisherPublic Library of Science
dc.rightsAttribution 3.0 United States
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/
dc.subjectIn vitro neuronal cultures
dc.subjectNeuronal dynamics
dc.subjectElectrical stimulation
dc.subjectNeural networks
dc.subjectElectrode recording
dc.titleTime-Dependent Increase in Network Response to Stimulation
dc.typeArticle

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