MIAMI: A Graphical Interface Web-Tool for Integrated miRNA-mRNA Interaction Analyses in Drosophila melanogaster

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dc.contributor.advisorWillett, James D.
dc.contributor.authorPatel, Jaimin
dc.creatorPatel, Jaimin
dc.date2012-11-26
dc.date.accessioned2013-02-18T20:12:47Z
dc.date.availableNO_RESTRICTION
dc.date.available2013-02-18T20:12:47Z
dc.date.issued2013-02-18
dc.description.abstractThis thesis describes the design and implementation of a web-based tool – MIAMI (miRNA and mRNA integrated analysis) – that enables integrative analysis of target predictions, miRNA and gene expression data. MIAMI is divided into two parts: the query section and the analysis section. The query section allows the user to retrieve and browse updated miRNA-mRNA pairs predicted using a number of different computational algorithms such as PITA, miRanda and Target Scan as well as Boolean combinations of these algorithms. The analysis section comprises a multi-step procedure for (i) performing various statistical analyses of mRNA and miRNA expression data; (ii) visualization of networks of the highest confidence miRNA and mRNA interactions and; (iii) retrieval of gene, miRNA and disease-specific information available in several public databases via scientific literature text-mining.
dc.identifier.urihttps://hdl.handle.net/1920/8026
dc.language.isoen
dc.subjectMiRNA-mRNA
dc.subjectDrosophilia melanogaster
dc.subjectGraphical Interface Web Tool
dc.subjectMIAMI
dc.subjectTarget prediction algorithms
dc.subjectNetwork Visualization
dc.titleMIAMI: A Graphical Interface Web-Tool for Integrated miRNA-mRNA Interaction Analyses in Drosophila melanogaster
dc.typeThesis
thesis.degree.disciplineBioinformatics and Computational Biology
thesis.degree.grantorGeorge Mason University
thesis.degree.levelMaster's
thesis.degree.nameMaster of Science in Bioinformatics and Computational Biology

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