Exosomal Small RNA Survey of Bovine Milk: Discovery of Small RNA Signatures across Bacterial Infections of the Bovine Mammary Glands

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dc.contributor.advisorSonstegard, Tad
dc.contributor.advisorSeto, Donald
dc.contributor.authorAswath, Kshama
dc.creatorAswath, Kshama
dc.date.accessioned2015-07-29T18:35:16Z
dc.date.available2015-07-29T18:35:16Z
dc.date.issued2015
dc.description.abstractMastitis, an endemic disease, affects the mammary glands of lactating cows and contributes to an estimated annual loss of two billion dollars to the U.S. dairy economy (Hogeveen, Huijps, & Lam, 2011). Many bacterial pathogens, for example, Streptococcus uberis, Staphylococcus aureus and Escherichia coli, if left undetected and untreated at sub-clinical stages of infection, can cause an endemic disease like mastitis (Barkema, Green, Bradley, & Zadoks, 2009). Mastitis negatively affects the quality and quantity of milk produced from a lactating animal (De Vliegher, Fox, Piepers, McDougall, & Barkema, 2012) and extensive use of antibiotics to treat this disease can have possible downstream implications on consumer safety, which, in turn pose a threat to human health. Recent research has shown the potential of circulating miRNAs as non-invasive biomarkers in disease diagnosis and therapeutics (Zen & Zhang, 2012). miRNAs present in the milk are shown to be packaged into exosomes, a type of extracellular micro vesicle secreted by various cells (Valadi et al., 2007).
dc.format.extent117 pages
dc.identifier.urihttps://hdl.handle.net/1920/9622
dc.language.isoen
dc.rightsCopyright 2015 Kshama Aswath
dc.subjectBioinformatics
dc.subjectBovine
dc.subjectExosomes
dc.subjectMastitis
dc.subjectMiRNA
dc.subjectNext Generation Sequencing
dc.titleExosomal Small RNA Survey of Bovine Milk: Discovery of Small RNA Signatures across Bacterial Infections of the Bovine Mammary Glands
dc.typeDissertation
thesis.degree.disciplineBioinformatics and Computational Biology
thesis.degree.grantorGeorge Mason University
thesis.degree.levelDoctoral

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