Theta-Burst LTP in the Dorsal Striatum: Its Development and Use to Illuminate Stratal Dynamics Underlying Skill Learning, and the Aberrant Learning Behind Addiction

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dc.contributor.advisorBlackwell, Kim T.
dc.contributor.authorHawes, Sarah Louise
dc.creatorHawes, Sarah Louise
dc.date.accessioned2015-07-29T18:35:17Z
dc.date.available2015-07-29T18:35:17Z
dc.date.issued2015
dc.description.abstractCorticostriatal plasticity facilitates action selection and skill learning through dynamic enhancement (“long term potentiation” or LTP) and reduction (“long term depression” or LTD) in communication strength between neurons. Striatal primary neurons are divided into two classes: motor-enhancing “direct” and motor-suppressing “indirect” pathway neurons. The regulation of plasticity in these two classes is critical because pathway imbalance is a noted feature in Parkinson’s disease, and strong class-specific plasticity accompanies exposure to drugs of abuse. Thus, it is important to understand striatal plasticity not only to identify neural learning mechanisms, but also because dysregulation of plasticity processes serving learning contributes to disease states.
dc.format.extent158 pages
dc.identifier.urihttps://hdl.handle.net/1920/9626
dc.language.isoen
dc.rightsCopyright 2015 Sarah Louise Hawes
dc.subjectNeurosciences
dc.subjectLearning
dc.subjectLTP
dc.subjectMemory
dc.subjectOpioids
dc.subjectPlasticity
dc.subjectStriatum
dc.titleTheta-Burst LTP in the Dorsal Striatum: Its Development and Use to Illuminate Stratal Dynamics Underlying Skill Learning, and the Aberrant Learning Behind Addiction
dc.typeDissertation
thesis.degree.disciplineNeuroscience
thesis.degree.grantorGeorge Mason University
thesis.degree.levelDoctoral

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