Neural Effects of Estrogen on Mitochondrial Lipids and Cardiolipin Levels and Distribution

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dc.contributor.advisorKabbani, Nadine
dc.creatorLebert, Nadege
dc.date2023-05-04
dc.date.accessioned2023-06-19T12:46:37Z
dc.date.available2023-06-19T12:46:37Z
dc.description.abstractA variety of lipid classes play important roles in neuronal structure and function. One of these lipids is cardiolipin, a phospholipid exclusive to the mitochondria and important to processes such as mitophagy and apoptosis through its differential oxidation. Estradiol (E2), a steroid sex hormone, is known to exert antioxidant effects in various cell types. I will establish a baseline lipidome in a line of neural cells and use E2-treatment conditions to determine if estrogen antioxidant effects are mediated through lipids, with a particular focus on cardiolipin. The results could contribute to understanding how hormonal changes can impact neural cell health and neurodegeneration.
dc.format.mediummasters theses
dc.identifier.urihttps://hdl.handle.net/1920/13347
dc.language.isoen
dc.rightsCopyright 2023 Nadege Lebert
dc.rights.urihttps://rightsstatements.org/vocab/InC/1.0
dc.subject.keywordsLipid
dc.subject.keywordsCardiolipin
dc.subject.keywordsMitochondria
dc.subject.keywordsNeurodegeneration
dc.subject.keywordsEstrogen
dc.titleNeural Effects of Estrogen on Mitochondrial Lipids and Cardiolipin Levels and Distribution
dc.typeText
thesis.degree.disciplineBiology
thesis.degree.grantorGeorge Mason University
thesis.degree.levelMaster's
thesis.degree.nameMaster of Science in Biology

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