GENOMIC RESOURCES FOR CRYPTOSPORIDIUM SPECIES, HUMAN PATHOGENS OF PUBLIC HEALTH SIGNIFICANCE IN DEVELOPING COUNTRIES

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dc.contributor.advisorSilva, Joana CVaisman, Iosif
dc.contributor.authorIfeonu, Olukemi O
dc.creatorIfeonu, Olukemi O
dc.date.accessioned2018-10-22T01:19:47Z
dc.date.available2018-10-22T01:19:47Z
dc.date.issued2017
dc.description.abstractCryptosporidium species are intracellular protozoan parasites, members of the phylum Apicomplexa that can infect the intestinal or gastric epithelial tissue of vertebrates, causing diarrhea. In immunocompromised individuals and young children, cryptosporidiosis can be life-threatening. Cryptosporidium was recently identified as a major cause of diarrhea-induced death of young children in developing countries. Despite the immense public health impact of Cryptosporidium infections in developing countries, no significant progress has been made towards developing a vaccine. Biological and technical challenges have impeded traditional vaccinology approaches to identify novel targets for the development of vaccines against this pathogen. The availability of genomic resources for multiple species in the genus has the potential to make a reverse vaccinology approach feasible. This dissertation describes the development and availability of new genomic tools and resources that should prove a valuable resource for the Cryptosporidium research community. This includes the annotated draft genome sequences of three species of Cryptosporidium, the Cryptosporidium hominis Gene Catalog, and the genome of a strain of anthroponotic Cryptosporidium parvum, and its analysis.
dc.format.extent66 pages
dc.identifier.urihttps://hdl.handle.net/1920/11245
dc.language.isoen
dc.rightsCopyright 2017 Olukemi O Ifeonu
dc.subjectBioinformatics
dc.subjectAnthroponotic
dc.subjectApicomplexan
dc.subjectCryptosporidium
dc.subjectGene catalog
dc.subjectImmunogen
dc.subjectReverse vaccinolgy
dc.titleGENOMIC RESOURCES FOR CRYPTOSPORIDIUM SPECIES, HUMAN PATHOGENS OF PUBLIC HEALTH SIGNIFICANCE IN DEVELOPING COUNTRIES
dc.typeDissertation
thesis.degree.disciplineBioinformatics and Computational Biology
thesis.degree.grantorGeorge Mason University
thesis.degree.levelPh.D.

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