COMPUTATIONAL ANALYSIS OF THE PHYLOGENOMIC RELATIONSHIPS OF HUMAN AND SIMIAN ADENOVIRUSES AND THE CROSS-SPECIES TRANSMISSIONS

Abstract

The phylogenetic relationships of HAdV and SAdV are not formally well defined by the International Committee on Taxonomy of Viruses (ICTV). All archived genomes will be analyzed at high resolution using genomics and bioinformatics to provide a comprehensive reference. Given their evolutionary closeness, possible zoonotic and anthroponosis transfers between human and non-human simian hosts will be examined using HAdV-E4 and SAdV-21 as examples, based on their clustering in the phylogenomic trees.