Flinn, Jane MBoggs, Katelyn Nicole2018-10-212018-10-212017https://hdl.handle.net/1920/11153Research in the field of Alzheimer’s disease (AD) often focuses on the early onset form (EOAD); however, the majority of AD cases are late onset (LOAD). The reason for this is the genetic nature of EOAD, and thus relative ease of developing animal models for EOAD through genetic manipulation. The present study was an attempt to model LOAD in mice by crossing the J20 mouse, which overexpresses human mutated amyloid precursor protein (hAPP), with the ApoE4 mouse, which expresses the E4 allele of the apolipoprotein, resulting in J20/E4 offspring. The E4 allele is the only known genetic risk factor for the development of LOAD.79 pagesenCopyright 2017 Katelyn Nicole BoggsNeurosciencesAlzheimer's diseaseApoE4APPBurrowingNestingDissertation