Hart, David MSarkissian, Alfred2018-10-222018-10-222017https://hdl.handle.net/1920/11297Despite the increase in scientific, monetary, and human resources devoted to drug discovery R&D, the annual number of FDA-approved drugs has been almost unchanged for decades. This study seeks clues to the R&D productivity paradox by exploring the drivers and barriers to innovation in the pharmaceutical industry. The main focus is on the contribution of science and knowledge form external sources to innovation.294 pagesenCopyright 2017 Alfred SarkissianPublic policyBreakthrough InnovationsDrug Discovery InnovationEroom’s LawInnovation SystemOrange BookPatent AnalysisDissertation