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Phosphorylation of Single Stranded RNA Virus Proteins and Potential for Novel Therapeutic Strategies

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dc.contributor.author Keck, Forrest
dc.contributor.author Ataey, Pouya
dc.contributor.author Amaya, Moushimi
dc.contributor.author Bailey, Charles
dc.contributor.author Narayanan, Aarthi
dc.date.accessioned 2016-07-27T16:56:04Z
dc.date.available 2016-07-27T16:56:04Z
dc.date.issued 2015-10-12
dc.identifier.citation Keck, Forrest, Pouya Ataey, Moushimi Amaya, Charles Bailey, and Aarthi Narayanan. “Phosphorylation of Single Stranded RNA Virus Proteins and Potential for Novel Therapeutic Strategies.” Viruses 7, no. 10 (October 12, 2015): 5257–73. doi:10.3390/v7102872. en_US
dc.identifier.uri https://hdl.handle.net/1920/10307
dc.description.abstract Post translational modification of proteins is a critical requirement that regulates function. Among the diverse kinds of protein post translational modifications, phosphorylation plays essential roles in protein folding, protein:protein interactions, signal transduction, intracellular localization, transcription regulation, cell cycle progression, survival and apoptosis. Protein phosphorylation is also essential for many intracellular pathogens to establish a productive infection cycle. Preservation of protein phosphorylation moieties in pathogens in a manner that mirrors the host components underscores the co-evolutionary trajectory of pathogens and hosts, and sheds light on how successful pathogens have usurped, either in part or as a whole, the host enzymatic machinery. Phosphorylation of viral proteins for many acute RNA viruses including Flaviviruses and Alphaviruses has been demonstrated to be critical for protein functionality. This review focuses on phosphorylation modifications that have been documented to occur on viral proteins with emphasis on acutely infectious, single stranded RNA viruses. The review additionally explores the possibility of repurposing Food and Drug Administration (FDA) approved inhibitors as antivirals for the treatment of acute RNA viral infections.
dc.description.sponsorship Publication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund. en_US
dc.language.iso en_US en_US
dc.publisher Multidisciplinary Digital Publishing Institute en_US
dc.subject post translational modification en_US
dc.subject viral protein en_US
dc.subject phosphorylation en_US
dc.subject therapeutics en_US
dc.subject kinase en_US
dc.subject antivirals en_US
dc.title Phosphorylation of Single Stranded RNA Virus Proteins and Potential for Novel Therapeutic Strategies en_US
dc.type Article en_US
dc.identifier.doi http://dx.doi.org/10.3390/v7102872


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