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Now showing items 1-20 of 153

Oxidized Extracellular DNA as a Stress Signal in Human Cells

Ermakov, Aleksei V.; Konkova, Marina S.; Kostyuk, Svetlana V.; Izevskaya, Vera L.; Baranova, Ancha; Veiko, Natalya N. (Hindawi Publishing Corporation, 2013-01)

The term “cell-free DNA” (cfDNA) was recently coined for DNA fragments from plasma/serum, while DNA present in in vitro cell culture media is known as extracellular DNA (ecDNA). Under oxidative stress conditions, the levels ...
Signaling Pathways Involved in Striatal Synaptic Plasticity are Sensitive to Temporal Pattern and Exhibit Spatial Specificity

Kim, BoHung; Hawes, Sarah L.; Gillani, Fawad; Wallace, Lane J.; Blackwell, Kim T. (Public Library of Science, 2013-03-14)

The basal ganglia is a brain region critically involved in reinforcement learning and motor control. Synaptic plasticity in the striatum of the basal ganglia is a cellular mechanism implicated in learning and neuronal ...
Improving remote sensing flood assessment using volunteered geographical data

Schnebele, E.; Cervone, G. (Copernicus Publications, 2013-03-19)

A new methodology for the generation of flood hazard maps is presented fusing remote sensing and volunteered geographical data. Water pixels are identified utilizing a machine learning classification of two Landsat remote ...
Understanding Electronic Medical Record Adoption in the United States: Communication and Sociocultural Perspectives

Nambisan, Priya; Kreps, Gary L.; Polit, Stan (JMIR Publications, 2013-03-26)

Background: This paper adopts a communication and sociocultural perspective to analyze the factors behind the lag in electronic medical record (EMR) adoption in the United States. Much of the extant research on this topic ...
CoreGenes3.5: a webserver for the determination of core genes from sets of viral and small bacterial genomes

Turner, Dann; Reynolds, Darren; Seto, Donald; Mahadevan, Padmanabhan (BioMed Central, 2013-04-08)

Background: CoreGenes3.5 is a webserver that determines sets of core genes from viral and small bacterial genomes as an automated batch process. Previous versions of CoreGenes have been used to classify bacteriophage genomes ...
The socio-cultural importance of Mauritia flexuosa palm swamps (aguajales) and implications for multi-use management in two Maijuna communities of the Peruvian Amazon

Gilmore, Michael P.; Endress, Bryan A.; Horn, Christa M. (BioMed Central, 2013-04-22)

Background Fruit from the palm Mauritia flexuosa (aguaje) is harvested throughout the Peruvian Amazon for subsistence and commercial purposes. Recent estimates suggest that residents of Iquitos, the largest city in the ...
Augmenting Weak Semantic Cognitive Maps with an “Abstractness” Dimension

Samsonovich, Alexei (Hindawi Publishing, 2013-04-29)

The emergent consensus on dimensional models of sentiment, appraisal, emotions, and values is on the semantics of the principal dimensions, typically interpreted as valence, arousal, and dominance. The notion of weak ...
Employment Growth through Labor Flow Networks

Guerrero, Omar A.; Axtell, Robert L. (Public Library of Science, 2013-05-02)

It is conventional in labor economics to treat all workers who are seeking new jobs as belonging to a labor pool, and all firms that have job vacancies as an employer pool, and then match workers to jobs. Here we develop ...
Mining social media and web searches for disease detection

Yang, Y. Tony; Horneffer, Michael; DiLisio, Nicole (PAGEPress, 2013-05-31)

Web-based social media is increasingly being used across different settings in the health care industry. The increased frequency in the use of the Internet via computer or mobile devices provides an opportunity for ...
An Evaluation Synthesis of US AIDS Drug Assistance Program Policy

Horneffer, Michael A.; Yang, Y. Tony (Scientific Research, 2013-06)

US Congress passed the CARE Act in 1990 in response to a dramatically growing need for resources to combat the AIDS epidemic. One of the programs contained in the Act was the AIDS Drug Assistance Program (ADAP), a ...
Not so cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction

Kabbani, Nadine (Frontiers, 2013-07-23)

Nicotine cigarette smoke is a large public health burden worldwide, contributing to various types of disease. Anti-tobacco media campaigns and control programs have significantly reduced smoking in the United States, yet ...
Functional Genomic Analyses of Two Morphologically Distinct Classes of Drosophila Sensory Neurons: Post-Mitotic Roles of Transcription Factors in Dendritic Patterning

Iyer, Eswar Prasad R.; Iyer, Srividya Chandramouli; Sullivan, Luis; Wang, Dennis; Meduri, Ramakrishna; Graybeal, Lacey L.; Cox, Daniel N. (Public Library of Science, 2013-08-15)

Background Neurons are one of the most structurally and functionally diverse cell types found in nature, owing in large part to their unique class specific dendritic architectures. Dendrites, being highly specialized ...
A Novel Application of Musculoskeletal Ultrasound Imaging

Eranki, Avinash; Cortes, Nelson; Ferenček3, Zrinka Gregurić; Siddhartha, Sikdar (Journal of Visualized Experiments, 2013-09)

Ultrasound is an attractive modality for imaging muscle and tendon motion during dynamic tasks and can provide a complementary methodological approach for biomechanical studies in a clinical or laboratory setting. Towards ...
Controlling Seizure-Like Events by Perturbing Ion Concentration Dynamics with Periodic Stimulation

Owen, Jeremy A.; Barreto, Ernest; Cressman, John R. (Public Library of Science, 2013-09-16)

We investigate the effects of adding periodic stimulation to a generic, conductance-based neuron model that includes ion concentration dynamics of sodium and potassium. Under conditions of high extracellular potassium, the ...
Environmental influences on neural systems of relational complexity

Kalbfleisch, M. Layne; deBettencourt, Megan T.; Kopperman, Rebecca; Banasiak, Meredith; Roberts, Joshua M.; Halavi, Maryam (Frontiers, 2013-09-26)

Constructivist learning theory contends that we construct knowledge by experience and that environmental context influences learning. To explore this principle, we examined the cognitive process relational complexity (RC), ...
Sequence and structure based models of HIV-1 protease and reverse transcriptase drug resistance

Masso, Majid; Vaisman, Iosif I. (BioMed Central, 2013-10-01)

Background Successful management of chronic human immunodeficiency virus type 1 (HIV-1) infection with a cocktail of antiretroviral medications can be negatively affected by the presence of drug resistant mutations in the ...
Dynamical structure underlying inverse stochastic resonance and its implications

Uzuntarla, Muhammet; Cressman, John R.; Ozer, Mahmut; Barreto, Ernest (American Physical Society, 2013-10-31)

We investigate inverse stochastic resonance (ISR), a recently reported phenomenon in which the spiking activity of a Hodgkin-Huxley model neuron subject to external noise exhibits a pronounced minimum as the noise intensity ...
Knowledge-based compact disease models identify new molecular players contributing to early-stage Alzheimer’s disease

Mayburd, Anatoly; Baranova, Ancha (BioMed Central, 2013-11-07)

Background High-throughput profiling of human tissues typically yield as results the gene lists comprised of a mix of relevant molecular entities with multiple false positives that obstruct the translation of such results ...
Four-body atomic potential for modeling protein-ligand binding affinity: application to enzyme-inhibitor binding energy prediction

Masso, Majid (BioMed Central, 2013-11-08)

Background : Models that are capable of reliably predicting binding affinities for protein-ligand complexes play an important role the field of structure-guided drug design. Methods : Here, we begin by applying the ...
The Approach to Sample Acquisition and Its Impact on the Derived Human Fecal Microbiome and VOC Metabolome

Couch, Robin D.; Navarro, Karl; Sikaroodi, Masoumeh; Gillevet, Pat; Forsyth, Christopher B.; Mutlu, Ece; Engen, Phillip A.; Keshavarzian, Ali (Public Library of Science, 2013-11-18)

Recent studies have illustrated the importance of the microbiota in maintaining a healthy state, as well as promoting disease states. The intestinal microbiota exerts its effects primarily through its metabolites, and ...

Now showing items 1-20 of 153

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