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Not so cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction

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dc.contributor.author Kabbani, Nadine
dc.date.accessioned 2015-10-29T16:00:09Z
dc.date.available 2015-10-29T16:00:09Z
dc.date.issued 2013-07-23
dc.identifier.citation Kabbani N (2013) Not so cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction. Front. Pharmacol. 4:95. doi: 10.3389/fphar.2013.00095 en_US
dc.identifier.uri https://hdl.handle.net/1920/9997
dc.description.abstract Nicotine cigarette smoke is a large public health burden worldwide, contributing to various types of disease. Anti-tobacco media campaigns and control programs have significantly reduced smoking in the United States, yet trends for menthol cigarette smoking have not been as promising. Menthol cigarette smoking is particularly prevalent among young adults and African Americans, with implications for long-term impacts on health care. Continuing high rates of menthol cigarette addiction call into question the role of menthol in nicotine addiction. To date, a biological basis for the high rate of addiction and relapse among menthol cigarette smokers has not been defined. Studies have demonstrated a role for menthol in the metabolism of nicotine in the body. More recent findings now reveal an interaction between menthol and the nicotinic acetylcholine (nACh) receptor in cells. This receptor is central to the actions of nicotine in the brain, and plays an important role in nicotine addiction. The newly discovered effect of menthol on nACh receptors may begin to explain the unique addictive properties of menthol cigarettes.
dc.description.sponsorship This work is supported by a VYTP Grant Award on Research on the Causes and Prevention of Youth Tobacco to Nadine Kabbani. Publication of this article was funded in part by the George Mason University Libraries Open Access Publishing Fund. en_US
dc.language.iso en_US en_US
dc.publisher Frontiers en_US
dc.rights Attribution 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by/3.0/us/ *
dc.subject menthol en_US
dc.subject addiction research en_US
dc.subject African Americans en_US
dc.subject nicotinic receptors en_US
dc.subject tobacco en_US
dc.title Not so cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction en_US
dc.type Article en_US
dc.identifier.doi http://dx.doi.org/10.3389/fphar.2013.00095


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