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Role of KCNRG in B-CELL Chronic Lymphocytic Leukemia

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dc.contributor.author Birerdinc, Aybike
dc.creator Birerdinc, Aybike
dc.date 2008-12-02
dc.date.accessioned 2008-12-22T21:05:08Z
dc.date.available NO_RESTRICTION en
dc.date.available 2008-12-22T21:05:08Z
dc.date.issued 2008-12-22T21:05:08Z
dc.identifier.uri https://hdl.handle.net/1920/3365
dc.description.abstract B-cell chronic lymphocyte leukemia (B-CLL) accounts for approximately 30% of all leukemias in the Western world and has so far been treated with variable success. The newly characterized KCNRG gene has been mapped to chromosome 13q14.3. KCNRG is thought to be a tumor suppressor gene involved in the development of B-cell chronic lymphocytic leukemia due to its significant homology to the tetramerization (T1) domain of the voltage-gated potassium channels (Kv channels) and an ability to suppress growth-stimulating Kv currents. Since point mutations of KCNRG have not been found in B-CLL samples, a novel approach for its study based on a haploinsufficiency model was suggested. The aim of this study is to determine whether the KCNRG gene functions as growth suppressor in tumor cell lines and to elucidate a putative role for the loss of this gene in the development and the progression of B-CLL. Overexpression studies of KCNRG were performed in an attempted to determine the involvement of KCNRG in apoptosis, differentiation, and invasion of cultured human tumor cells, and the effects of overexpression of KCNRG on gene expression and proteomics profiles were quantified.
dc.language.iso en_US en
dc.subject KCNRG en_US
dc.subject B-CLL en_US
dc.subject Haploinsufficiency en_US
dc.subject Tumor Suppressor Gene (TSG) en_US
dc.subject 13q14 en_US
dc.subject Potassium Channels en_US
dc.title Role of KCNRG in B-CELL Chronic Lymphocytic Leukemia en
dc.type Dissertation en
thesis.degree.name Doctor of Philosophy in Biosciences en
thesis.degree.level Doctoral en
thesis.degree.discipline Biosciences en
thesis.degree.grantor George Mason University en


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