Exact Properties of Restricted Randomization Procedures

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dc.contributor.advisorRosenberger, William F.
dc.contributor.authorShao, Hui
dc.creatorShao, Hui
dc.date.accessioned2016-04-19T19:29:44Z
dc.date.available2016-04-19T19:29:44Z
dc.date.issued2015
dc.description.abstractRestricted randomization is employed in clinical trials to achieve balanced or near balanced treatment assignments, but is associated with a loss of randomness. For example, the permuted block design, probably the most commonly used restricted randomization procedure, randomizes patients block by block and achieves perfect balance within each block. However, there is at least one predictable treatment assignment within each block. To avoid deterministic treatment allocation in the permuted block design, many clinical trialists prefer randomizing the block sizes as well. While such a procedure is rarely formalized, it is generally assumed that the design will be less predictable.
dc.format.extent106 pages
dc.identifier.urihttps://hdl.handle.net/1920/10199
dc.language.isoen
dc.rightsCopyright 2015 Hui Shao
dc.subjectStatistics
dc.subjectClinical trials
dc.subjectImbalance
dc.subjectPredictability
dc.subjectRandom block design
dc.subjectRestricted randomization
dc.subjectSelection bias
dc.titleExact Properties of Restricted Randomization Procedures
dc.typeDissertation
thesis.degree.disciplineStatistical Science
thesis.degree.grantorGeorge Mason University
thesis.degree.levelDoctoral

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