Within-Cluster Resampling Methods for Clustered Receiver Operating Characteristic (ROC) Data

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dc.contributor.advisorTang, Liansheng
dc.contributor.authorMiao, Zhuang
dc.creatorMiao, Zhuang
dc.date.accessioned2015-02-12T02:59:54Z
dc.date.available2015-02-12T02:59:54Z
dc.date.issued2014
dc.description.abstractThe diagnostic studies in which each patient has several diseased and nondiseased observations generate clustered ROC data. Within the same cluster, observations are naturally correlated, and the cluster size may be random. The traditional ROC methods on clustered data can result in a biased variance estimator and subsequently lead to incorrect statistical inference. We introduce resampling methods on clustered ROC data to account for the within-cluster correlation. The within-cluster resampling ROC methods work as follows. First, one observation is randomly selected from each patient/cluster, and then the traditional ROC methods are applied on the resampled data to obtain resampled ROC estimates. These steps are performed many times and the average of resampled ROC estimates is the final estimator. The proposed methods do not require a specific within-cluster correlation structure and yield valid estimators while accounting for the within-cluster correlation. We compare the proposed methods with existing methods in extensive simulation studies and apply the proposed methods to two eye rating examples.
dc.format.extent149 pages
dc.identifier.urihttps://hdl.handle.net/1920/9189
dc.language.isoen
dc.rightsCopyright 2014 Zhuang Miao
dc.subjectStatistics
dc.subjectBiostatistics
dc.subjectClustered ROC Data
dc.subjectROC Curve
dc.subjectWithin-Cluster Resampling
dc.titleWithin-Cluster Resampling Methods for Clustered Receiver Operating Characteristic (ROC) Data
dc.typeDissertation
thesis.degree.disciplineStatistical Science
thesis.degree.grantorGeorge Mason University
thesis.degree.levelDoctoral

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