Molecular Biomarkers and Network Analyses of Neuron-type Connectivity Reveal Cloaked Insights into Hippocampal Function
Date
2016
Authors
Rees, Christopher Loren
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Abstract
To launch Hippocampome.org, a framework for classifying neuron types in the rodent hippocampus, we assembled >14,000 pieces of experimental evidence supporting knowledge of approximately 3,700 properties for 122 neuron types. This resource, the first comprehensive machine-readable neuron inventory for a mammalian cortical region, provides an opportunity to analyze the hippocampus in novel ways and garner unique insights into its intricate structure and enigmatic function. Here, I describe my two-pronged attack on the sub-cellular and cellular fronts.
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Keywords
Neurosciences, Bioinformatics, Connectomics, Graph theory, Hippocampus, Molecular markers, Neuroinformatics, Neuron types